Publications
The laboratory leader´s interest towards the eye´s retina was initially based on the realization that the retina manifests pathological changes in diseases that are primary known as brain diseases.
2025
Female sex is a risk factor for exacerbated lipid peroxidation and disease in murine retinitis pigmentosa
Katri Vainionpää, Anna Kalatanova, Umair Seemab, Ahmed B. Montaser, Henri Leinonen.
Redox Biology
Mechanism of biomimetic virus-like nanoparticles in triggering immune response elucidated by proteomics
Jiajia Wang, Ahmed Montaser, Minna Sivonen, Henri Leinonen, Lucas Nygård, Tuure Kinnunen, Sini Pitkänen, Anna-Liisa Levonen-Harju, Enkhzaya Batnasan, Leena Latonen, Jussi Hepojoki, Leyuan Ma, Vesa-Pekka Lehto, Wujun Xu.
Colloids and Surfaces B: Biointerfaces
Presynaptic Changes in Mouse Rod Photoreceptors During Early Retinitis Pigmentosa
Elias Roihuvuo; Lee Sturgis; Ahmed B. Montaser; Marcin Tabaka; Elliot H. Choi; Deepa Mathew; Anthi-Styliani Makiou; Kristiina M. Huttunen; Krzysztof Palczewski; Frans Vinberg; Henri Leinonen.
Investigative Ophthalmology & Visual Science
Drug-Free Approach to Regulate Undruggable Proto-Oncogene MYC Using Biomimetic Porous Nanoparticles for Cancer Immunotherapy
Happonen, Emilia; Dang, Yijing; Wang, Jiajia; Saarela, Silja; Sivonen, Minna; Zakir, Mohammed; Laari, Milla-Iida; Constantinou, Yiannis; Tamarov, Konstantin; Hakkarainen, Henri; Montaser, Ahmed Bisher; Leinonen, Henri; Küblbeck, Jenni; Örd, Tiit; Taipale, Mari; Kaikkonen, Minna; Liu, Ruixian; Klefström, Juha; Yu, Haijun; Xu, Zhiai; Lehto, Vesa-Pekka; Xu, Wujun.
ACS Applied Materials & Interfaces
Computational drug repurposing: approaches, evaluation of in silico resources and case studies
Tanoli, Ziaurrehman; Fernández-Torras, Adrià; Özcan, Umut Onur; Kushnir, Aleksandr; Nader, Kristen Michelle; Gadiya, Yojana; Fiorenza, Laura; Ianevski, Aleksandr; Vähä-Koskela, Markus; Miihkinen, Mitro; Seemab, Umair; Leinonen, Henri; Seashore-Ludlow, Brinton; Tampere, Marianna; Kalman, Adelinn; Ballante, Flavio; Benfenati, Emilio; Saunders, Gary; Potdar, Swapnil; Gómez García, Ismael; García-Serna, Ricard; Talarico, Carmine; Beccari, Andrea Rosario; Schaal, Wesley; Polo, Andrea; Costantini, Sus.
Nature Reviews Drug Discovery
Cyclic nucleotide signaling as a drug target in retinitis pigmentosa
Vainionpää, Katri; Montaser, Ahmed B; Leinonen, Henri.
FEBS Letters
2024
Retinal proteome profiling of inherited retinal degeneration across three different mouse models suggests common drug targets in retinitis pigmentosa
Montaser, Ahmed B; Gao, Fangyuan; Peters, Danielle; Vainionpää, Katri; Zhibin, Ning; Skowronska-Krawczyk, Dorota; Figeys, Daniel; Palczewski, Krzysztof; Leinonen, Henri.
Molecular and Cellular Proteomics
A combination treatment based on drug repurposing demonstrates mutation-agnostic efficacy in pre-clinical retinopathy models
Leinonen, Henri; Zhang, Jianye; Occelli, Laurence M; Seemab, Umair; Choi, Elliot H; LP Marinho, Luis Felipe; Querubin, Janice; Kolesnikov, Alexander V; Galinska, Anna; Kordecka, Katarzyna; Hoang, Thanh; Lewandowski, Dominik; Lee, Timothy T; Einstein, Elliott E; Einstein, David E; Dong, Zhiqian; Kiser, Philip D; Blackshaw, Seth; Kefalov, Vladimir J; Tabaka, Marcin; Foik, Andrzej; Petersen-Jones, Simon M; Palczewski, Krzysztof.
Nature Communications
Synthesis and Biological Analysis of Iso-dimethyltryptamines in a Model of Light-Induced Retinal Degeneration
Ethan J Pazur, Anna Kalatanova, Nikhil R Tasker, Katri Vainionpää, Henri Leinonen, Peter Wipf.
ACS Medicinal Chemistry Letters
Metabolic characteristics of transmembrane prolyl 4-hydroxylase (P4H-TM) deficient mice
Ala-Nisula, Tuulia; Halmetoja, Riikka; Leinonen, Henri; Kurkela, Margareta; Lipponen, Henna-Riikka; Sakko, Samuli; Karpale, Mikko; Salo, Antti M; Sissala, Niina; Röning, Tapio; Raza, Ghulam S; Mäkelä, Kari A; Thevenot, Jérôme; Herzig, Karl-Heinz; Serpi, Raisa; Myllyharju, Johanna; Tanila, Heikki; Koivunen, Peppi; Dimova, Elitsa Y.
Pflügers Archiv - European Journal of Physiology
Sex-Specific Early Retinal Dysfunction in Mutant TDP-43 Transgenic Mice
Ju Gao, Henri Leinonen, Evan J Wang, Mao Ding, George Perry, Krzysztof Palczewski, Xinglong Wang.
Journal of Alzheimer’s Disease
2023
Stress resilience-enhancing drugs preserve tissue structure and function in degenerating retina via phosphodiesterase inhibition
Jennings C Luu, Aicha Saadane, Henri Leinonen, Elliot H Choi, Fangyuan Gao, Dominik Lewandowski, Maximilian Halabi, Christopher L Sander, Arum Wu, Jacob M Wang, Rupesh Singh, Songqi Gao, Emma M Lessieur, Zhiqian Dong, Grazyna Palczewska, Robert F Mullins, Neal S Peachey, Philip D Kiser, Marcin Tabaka, Timothy S Kern, Krzysztof Palczewski.
The Proceedings of the National Academy of Sciences U S A
Neural and Müller glial adaptation of the retina to photoreceptor degeneration
Henri Leinonen, Edward Bull, Zhongjie Fu.
Neural Regeneration Research
2022
Retinoid therapy restores eye-specific cortical responses in adult mice with retinal degeneration
Carey Y L Huh, Henri Leinonen, Taylor Nakayama, Julia R Tomasello, Jianye Zhang, Jack Zeitoun, John P Peach, Maximilian Halabi, Jianying Z Kiser, Krzysztof Palczewski, Philip D Kiser, Sunil P Gandhi.
Current Biology
Visual System Hyperexcitability and Compromised V1 Receptive Field Properties in Early-Stage Retinitis Pigmentosa in Mice
Henri Leinonen, David C Lyon, Krzysztof Palczewski, Andrzej T Foik.
eNeuro
In vivo base editing rescues cone photoreceptors in a mouse model of early-onset inherited retinal degeneration
Elliot H Choi, Susie Suh, Andrzej T Foik, Henri Leinonen, Gregory A Newby, Xin D Gao, Samagya Banskota, Thanh Hoang, Samuel W Du, Zhiqian Dong, Aditya Raguram, Sajeev Kohli, Seth Blackshaw, David C Lyon, David R Liu, Krzysztof Palczewski.
Nature Communications
Inhibition of ceramide accumulation in AdipoR1-/- mice increases photoreceptor survival and improves vision
Lewandowski D, Foik AT, Smidak R, Choi EH, Zhang J, Hoang T, Tworak A, Suh S, Leinonen H, Dong Z, Pinto AF, Tom E, Luu J, Lee J, Ma X, Bieberich E, Blackshaw S, Saghatelian A, Lyon DC, Skowronska-Krawczyk D, Tabaka M, Palczewski K.
JCI Insight
VCP/p97 inhibitor CB-5083 modulates muscle pathology in a mouse model of VCP inclusion body myopathy
Cheng C, Weiss L, Leinonen H, Shmara A, Yin HZ, Ton T, Do A, Lee J, Ta L, Mohanty E, Vargas J, Weiss J, Palczewski K, Kimonis V.
Journal of Translational Medicine